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Tg(Myh6-Acsl1)O7Jesc
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-Acsl1)O7Jesc
Name: transgene insertion O7, Jean E Schaffer
MGI ID: MGI:3639517
Synonyms: MHC-ACS O7
Transgene: Tg(Myh6-Acsl1)O7Jesc  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Acsl1)O7Jesc expresses 1 gene
 
Mutation detailsThe murine adipocyte Acsl1 cDNA containing a Myc tag is under the control of an alpha-mysoin heavy chain promoter construct that contains the last exon of the beta-myosin heavy chain gene, the alpha-myosin heavy chain promoter, and the first three untranslated exons of the alpha-myosin heavy chain gene. See an 11-fold increase in Acsl1 protein specifically in the heart. (J:68639)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:68639 Chiu HC, et al., A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest. 2001 Apr;107(7):813-22
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory