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Targeted Allele Detail
Symbol: Cd4tm1Jrp
Name: CD4 antigen; targeted mutation 1, Jane R Parnes
MGI ID: MGI:3639344
Synonyms: Cd4low
Gene: Cd4  Location: Chr6:124864692-124888221 bp, - strand  Genetic Position: Chr6, 59.17 cM
Germline Transmission:  Earliest citation of germline transmission: J:45168
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 10, 3' to the coding sequences of the gene. This allele expresses a twofold lower level of the encoded protein in the thymus and thus behaves as a hypomorph. (J:45168)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd4 Mutation:  65 strains or lines available
Original:  J:45168 Frank GD, et al., The level of CD4 surface protein influences T cell selection in the thymus. J Immunol. 1998 Jan 15;160(2):634-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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