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Targeted Allele Detail
Symbol: Reltm1Brv
Name: reticuloendotheliosis oncogene; targeted mutation 1, Rodrigo Bravo
MGI ID: MGI:3639342
Synonyms: c-reldeltaCT
Gene: Rel  Location: Chr11:23736847-23770969 bp, - strand  Genetic Position: Chr11, 14.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:46911
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA termination codon was introduced at codon 366 followed by a polyadenylation signal and neomycin selection cassette. This was inserted at the beginning of exon 10 such that exon 10, encoding the transcriptional activation domain, was not expressed. Labelling and immunoprecipitation experiments in mutant splenocytes demonstrated that a stable, truncated form of the encoded protein is expressed from this allele. (J:46911)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rel Mutation:  30 strains or lines available
Original:  J:46911 Carrasco D, et al., Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein. J Exp Med. 1998 Apr 6;187(7):973-84
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory