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Targeted Allele Detail
Symbol: Cd8atm1.1Kio
Name: CD8 antigen, alpha chain; targeted mutation 1.1, Dimitris Kioussis
MGI ID: MGI:3630292
Synonyms: deltaCII mutant
Gene: Cd8a  Location: Chr6:71350411-71356155 bp, + strand  Genetic Position: Chr6, 32.14 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:76799
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsTwo DNAaseI hypersensitive sites upstream of the Cd8a gene, HSS1 and HSS2, were deleted by homologous recombination. These sites are thought to contain regulatory sequences that control Cd8a expression. Targeting took place in ES cells homozygous for the Tg(Prm-cre)70Og transgene, which expresses Cre recombinase in male germ cells. An inserted loxP-flanked neomycin selection cassette was deleted by Cre-mediated recombination upon transmission from male chimeric mice. (J:76799)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd8a Mutation:  25 strains or lines available
Original:  J:76799 Garefalaki A, et al., Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences. Immunity. 2002 May;16(5):635-47
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory