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Cd8atm1.1Kio
Targeted Allele Detail
Nomenclature
Symbol: Cd8atm1.1Kio
Name: CD8 antigen, alpha chain; targeted mutation 1.1, Dimitris Kioussis
MGI ID: MGI:3630292
Synonyms: deltaCII mutant
Gene: Cd8a  Location: Chr6:71373427-71379173 bp, + strand  Genetic Position: Chr6, 32.14 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76799
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTwo DNAaseI hypersensitive sites upstream of the Cd8a gene, HSS1 and HSS2, were deleted by homologous recombination. These sites are thought to contain regulatory sequences that control Cd8a expression. Targeting took place in ES cells homozygous for the Tg(Prm-cre)70Og transgene, which expresses Cre recombinase in male germ cells. An inserted loxP-flanked neomycin selection cassette was deleted by Cre-mediated recombination upon transmission from male chimeric mice. (J:76799)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd8a Mutation:  19 strains or lines available
References
Original:  J:76799 Garefalaki A, et al., Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences. Immunity. 2002 May;16(5):635-47
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory