Gsc2^tm1Ais
Targeted Allele Detail

Summary

• Symbol: Gsc2^tm1Ais
• Name: goosecoid homebox 2; targeted mutation 1, Arthur I Skoultchi
• MGI ID: MGI:3630279
• Synonyms: Gscl^-
• Gene: Gsc2 Location: Chr16:17730978-17732891 bp, - strand Genetic Position: Chr16, 11.1 cM
• Alliance: Gsc2^tm1Ais page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50872
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.3 kb genomic fragment containing all three coding exons, 840 bp of the putative promoter and 100 bp 3' relative to the termination codon was deleted and replaced with a hygromycin selection cassette, loxP site and a promoterless puromycin resistance gene. RT-PCR analysis confirmed that no detectable transcript was expressed from this allele. (J:50872)

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsc2 Mutation: 13 strains or lines available

References

• Original: J:50872 Saint-Jore B, et al., Goosecoid-like (Gscl), a candidate gene for velocardiofacial syndrome, is not essential for normal mouse development. Hum Mol Genet. 1998 Nov;7(12):1841-9
• All: 2 reference(s)