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Ptgs2tm1.1Fun
Targeted Allele Detail
Nomenclature
Symbol: Ptgs2tm1.1Fun
Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1.1, Colin D Funk
MGI ID: MGI:3629677
Synonyms: (COX)-2-, Ptgs2Y385F, Y371F
Gene: Ptgs2  Location: Chr1:150100031-150108227 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109548
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsThis allele was generated by Cre mediated recombination of Ptgs2tm1Fun, resulting in the loss of the neomycin selection cassette. (J:109548)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:  14 strains or lines available
References
Original:  J:109548 Yu Y, et al., Genetic model of selective COX2 inhibition reveals novel heterodimer signaling. Nat Med. 2006 Jun;12(6):699-704
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory