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Pcsk1N222D
Chemically induced Allele Detail
Nomenclature
Symbol: Pcsk1N222D
Name: proprotein convertase subtilisin/kexin type 1; N222D
MGI ID: MGI:3629669
Synonyms: Pc1N222D
Gene: Pcsk1  Location: Chr13:75089826-75132498 bp, + strand  Genetic Position: Chr13, 40.63 cM, cytoband C2
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
    An A to G transition resulted in an asparagines to aspartic acid at codon 222. (J:109531)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pcsk1 Mutation:  24 strains or lines available
References
Original:  J:109531 Lloyd DJ, et al., Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice. Hum Mol Genet. 2006 Jun 1;15(11):1884-93
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/08/2018
MGI 6.12
The Jackson Laboratory