About   Help   FAQ
Ncstntm1Rroz
Targeted Allele Detail
Nomenclature
Symbol: Ncstntm1Rroz
Name: nicastrin; targeted mutation 1, Richard Rozmahel
MGI ID: MGI:3629090
Synonyms: Ncstntm1Ut
Gene: Ncstn  Location: Chr1:172066013-172082795 bp, - strand  Genetic Position: Chr1, 79.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108976
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exon 3. RT-PCR demonstrated absence of wild-type protein in mutants. (J:108976)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncstn Mutation:  24 strains or lines available
References
Original:  J:108976 Nguyen V, et al., Loss of nicastrin elicits an apoptotic phenotype in mouse embryos. Brain Res. 2006 May 1;1086(1):76-84
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/08/2017
MGI 6.10
The Jackson Laboratory