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Ncstntm1Rroz
Targeted Allele Detail
Nomenclature
Symbol: Ncstntm1Rroz
Name: nicastrin; targeted mutation 1, Richard Rozmahel
MGI ID: MGI:3629090
Synonyms: Ncstntm1Ut
Gene: Ncstn  Location: Chr1:172066013-172082795 bp, - strand  Genetic Position: Chr1, 79.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108976
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exon 3. RT-PCR demonstrated absence of wild-type protein in mutants. (J:108976)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncstn Mutation:  21 strains or lines available
References
Original:  J:108976 Nguyen V, et al., Loss of nicastrin elicits an apoptotic phenotype in mouse embryos. Brain Res. 2006 May 1;1086(1):76-84
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory