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Targeted Allele Detail
Symbol: Stx1atm1Tfuj
Name: syntaxin 1A (brain); targeted mutation 1, Tomonori Fujiwara
MGI ID: MGI:3629049
Synonyms: Synt1A-
Gene: Stx1a  Location: Chr5:135023482-135051100 bp, + strand  Genetic Position: Chr5, 74.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:109042
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace sequence encompassing exon 9 and part of exon 10, sequence encoding the H3 and transmembrane domains, with a neomycin resistance gene. Northern blot and Western blot analyses confirmed the absence of transcript and protein, respectively, from mutants. (J:109042)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stx1a Mutation:  19 strains or lines available
Phenotypic Similarity to Human Syndrome: neuropsychological disorders with serotoninergic defect in homozygous and heterozygous mice (J:171786)
Original:  J:109042 Fujiwara T, et al., Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity. J Neurosci. 2006 May 24;26(21):5767-76
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
The Jackson Laboratory