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Pnpla2tm1Rze
Targeted Allele Detail
Summary
Symbol: Pnpla2tm1Rze
Name: patatin-like phospholipase domain containing 2; targeted mutation 1, Rudolf Zechner
MGI ID: MGI:3629035
Synonyms: ATGL-, ATGL-ko
Gene: Pnpla2  Location: Chr7:141035111-141040656 bp, + strand  Genetic Position: Chr7, 86.81 cM, cytoband F5
Alliance: Pnpla2tm1Rze page
Increase in neutral lipid content in Abhd5tm1.1Rze/Abhd5tm1.1Rze and Pnpla2tm1Rze/Pnpla2tm1Rze livers

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108546
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the first exon including the translational start codon and the lipase consensus sequence motif (GXSXG). Northern analysis of white adipose tissue did not detect transcript in white adipose tissue from homozygous mutant mice. Similarly, western blot analysis of white adipose tissue from homozygous mutant mice did not detect protein. (J:108546)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pnpla2 Mutation:  33 strains or lines available
References
Original:  J:108546 Haemmerle G, et al., Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science. 2006 May 5;312(5774):734-7
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory