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Pth1rtm4Hmk
Targeted Allele Detail
Nomenclature
Symbol: Pth1rtm4Hmk
Name: parathyroid hormone 1 receptor; targeted mutation 4, Henry M Kronenberg
MGI ID: MGI:3628795
Synonyms: PTHRD
Gene: Pth1r  Location: Chr9:110722085-110747145 bp, - strand  Genetic Position: Chr9, 60.56 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108984
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to mutate the EKKY in the second intracellular loop to DSEL. A neomycin gene inserted into the intron between exons E1 and E2 was subsequently removed via transient cre expression. (J:108984)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pth1r Mutation:  15 strains or lines available
References
Original:  J:108984 Guo J, et al., The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev Cell. 2002 Aug;3(2):183-94
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory