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Gene trapped Allele Detail
Symbol: MpiGt(OST90588)Lex
Name: mannose phosphate isomerase; gene trap OST90588, Lexicon Genetics
MGI ID: MGI:3628756
Synonyms: Mpi-, MpiGt(VICTR48)1Lex
Gene: Mpi  Location: Chr9:57544256-57552763 bp, - strand  Genetic Position: Chr9, 31.05 cM, cytoband C
Mutant Cell Line:  OST90588 (Lexicon Genetics)
Germline Transmission:  Earliest citation of germline transmission: J:109220
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector
Mutation detailsThe insertion of the VICTR48 vector into intron 1 resulted in the splicing of 5' exonic sequences to a neomycin resistance cassette. The vector contained long terminal repeats, neo-pA, BTK and additional LTR sequence. The final product was a fusion of exon 1 and the neo. Protein expression was not detected in mutant embryos. (J:109220)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mpi Mutation:  15 strains or lines available
Original:  J:109220 DeRossi C, et al., Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality. J Biol Chem. 2006 Mar 3;281(9):5916-27
All:  2 reference(s)

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MGI 6.04
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