Nptx1^tm1Mspn
Targeted Allele Detail

Summary

• Symbol: Nptx1^tm1Mspn
• Name: neuronal pentraxin 1; targeted mutation 1, Mark S Perin
• MGI ID: MGI:3628746
• Synonyms: NARP^-, NP1^-
• Gene: Nptx1 Location: Chr11:119429545-119438579 bp, - strand Genetic Position: Chr11, 83.95 cM, cytoband E1-E2
• Alliance: Nptx1^tm1Mspn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62756
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and the signal peptide were replaced with a PGK-hprt cassette. Western blot failed to detect protein in mutants. (J:62756)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nptx1 Mutation: 24 strains or lines available

References

• Original: J:62756 Kirkpatrick LL, et al., Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. J Biol Chem. 2000 Jun 9;275(23):17786-92
• All: 7 reference(s)