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Artm3(AR)Dmr
Targeted Allele Detail
Nomenclature
Symbol: Artm3(AR)Dmr
Name: androgen receptor; targeted mutation 3, Diane M Robins
MGI ID: MGI:3628492
Synonyms: 48Q, AR48Q, Artm3Apl
Gene: Ar  Location: ChrX:98149721-98323215 bp, + strand  Genetic Position: ChrX, 42.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108849
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Artm3(AR)Dmr expresses 1 gene
 
Mutation detailsHuman androgen receptor amino acids 31 to 484 were inserted into the mouse locus. This allele contains 48 glutamine residues in the N terminal. Transient cre expression removed a floxed neo from the recombined locus. RT-PCR demonstrated higher levels of transcript in mutants than wild-type. Western blot showed that protein levels were also somewhat higher. (J:108849)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ar Mutation:  13 strains or lines available
References
Original:  J:108849 Albertelli MA, et al., Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice. Mol Endocrinol. 2006 Jun;20(6):1248-60
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory