Capn2^tm1Pag
Targeted Allele Detail

Summary

• Symbol: Capn2^tm1Pag
• Name: calpain 2; targeted mutation 1, Peter A Greer
• MGI ID: MGI:3628453
• Synonyms: Capn2^-
• Gene: Capn2 Location: Chr1:182294825-182345173 bp, - strand Genetic Position: Chr1, 84.93 cM
• Alliance: Capn2^tm1Pag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107240
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced exon 7. Exon 7 encodes 24 residues, including the active site asparagine at residue 286. (J:107240)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Capn2 Mutation: 34 strains or lines available

References

• Original: J:107240 Dutt P, et al., m-Calpain is required for preimplantation embryonic development in mice. BMC Dev Biol. 2006 Jan 24;6(1):3
• All: 1 reference(s)