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Targeted Allele Detail
Symbol: Dclk1tm1Caw
Name: doublecortin-like kinase 1; targeted mutation 1, Christopher A Walsh
MGI ID: MGI:3626361
Synonyms: Dclk-
Gene: Dclk1  Location: Chr3:55242364-55539068 bp, + strand  Genetic Position: Chr3, 26.53 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:105301
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA targeting vector was designed to delete exons 9-11, which encode the core of the kinase domain and are common to almost all known transcripts from the locus. A frame shift was introduced into the locus, generating multiple stop codons downstream of exon 9. (J:105301)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dclk1 Mutation:  23 strains or lines available
Original:  J:105301 Deuel TA, et al., Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron. 2006 Jan 5;49(1):41-53
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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