Kat6a^tm1Avo
Targeted Allele Detail

Summary

• Symbol: Kat6a^tm1Avo
• Name: K(lysine) acetyltransferase 6A; targeted mutation 1, Anne K Voss
• MGI ID: MGI:3626344
• Synonyms: Moz^delta
• Gene: Kat6a Location: Chr8:23349551-23433275 bp, + strand Genetic Position: Chr8, 11.42 cM
• Alliance: Kat6a^tm1Avo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108453
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A truncated gene was created by the in frame insertion of a neomycin resistance cassette into exon 16 at amino acid 1358. Northern blot detected a longer transcript than wild-type, indicating the correct insertion of the neo. Western blot failed to detect a Myst3-neo fusion protein in mutants. (J:108453)

Disease models

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat6a Mutation: 67 strains or lines available

References

• Original: J:108453 Thomas T, et al., Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells. Genes Dev. 2006 May 1;20(9):1175-86
• All: 12 reference(s)