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Kat6atm1Avo
Targeted Allele Detail
Nomenclature
Symbol: Kat6atm1Avo
Name: K(lysine) acetyltransferase 6A; targeted mutation 1, Anne K Voss
MGI ID: MGI:3626344
Synonyms: Mozdelta
Gene: Kat6a  Location: Chr8:22859535-22943259 bp, + strand  Genetic Position: Chr8, 11.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108453
Parent Cell Line:  MPI-II (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA truncated gene was created by the in frame insertion of a neomycin resistance cassette into exon 16 at amino acid 1358. Northern blot detected a longer transcript than wild-type, indicating the correct insertion of the neo. Western blot failed to detect a Myst3-neo fusion protein in mutants. (J:108453)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kat6a Mutation:  35 strains or lines available
References
Original:  J:108453 Thomas T, et al., Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells. Genes Dev. 2006 May 1;20(9):1175-86
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory