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Spontaneous Allele Detail
Symbol: Tlr4lps-2J
Name: toll-like receptor 4; defective lipopolysaccharide response 2 Jackson
MGI ID: MGI:3626283
Gene: Tlr4  Location: Chr4:66745788-66765338 bp, + strand  Genetic Position: Chr4, 34.66 cM
Strain of Origin:  BXD29-Tlr4lps-2J/J
Allele Type:    Spontaneous
Mutation:    Insertion
Mutation detailsAttempts to amplify the segment of exon 3 from the C57BL/6J DNA in the BXD29/TyJ strain representing nucleotides 279 - 708 of the cDNA sequence led to the discovery, near the 3' end of the gene, of a large insertion composed primarily of a repetitive sequence which exists in ~ 200 locations throughout the mouse genome. The insertion also includes a 239-bp sequence identical to a segment of Chr 10 between nucleotides 51,365,897 and 51,366,135 (build not identified). None of the endogenous gene is deleted, but the insertion is flanked at both ends by the same 8-nucleotide sequence (TCTTTCTT). Quantitative RT-PCR analysis detects no reduction in transcribed mRNA in peritoneal macrophages from mutant mice; however, these cells are not stained by antibodies against the encoded protein. (J:107391)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:  71 strains or lines available
Recombinant inbred strain BXD29 carries this allele.
Original:  J:107391 Cook DN, et al., Spontaneous mutations in recombinant inbred mice: mutant toll-like receptor 4 (Tlr4) in BXD29 mice. Genetics. 2006 Mar;172(3):1751-5
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
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