About   Help   FAQ
Ddotm1Snyd
Targeted Allele Detail
Nomenclature
Symbol: Ddotm1Snyd
Name: D-aspartate oxidase; targeted mutation 1, Solomon H Snyder
MGI ID: MGI:3625623
Synonyms: Ddo-
Gene: Ddo  Location: Chr10:40630011-40649931 bp, + strand  Genetic Position: Chr10, 22.0 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106267
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a neomycin resistance cassette by homologous recombination. The targeting event introduced a frame shift. Northern blot failed to detect transcript in mutant liver and kidney. Western blot confirmed absence of protein, as well. (J:106267)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddo Mutation:  4 strains or lines available
References
Original:  J:106267 Huang AS, et al., D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice. J Neurosci. 2006 Mar 8;26(10):2814-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/16/2017
MGI 6.09
The Jackson Laboratory