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Ddotm1Snyd
Targeted Allele Detail
Nomenclature
Symbol: Ddotm1Snyd
Name: D-aspartate oxidase; targeted mutation 1, Solomon H Snyder
MGI ID: MGI:3625623
Synonyms: Ddo-
Gene: Ddo  Location: Chr10:40630011-40649931 bp, + strand  Genetic Position: Chr10, 22.0 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106267
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a neomycin resistance cassette by homologous recombination. The targeting event introduced a frame shift. Northern blot failed to detect transcript in mutant liver and kidney. Western blot confirmed absence of protein, as well. (J:106267)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddo Mutation:  4 strains or lines available
References
Original:  J:106267 Huang AS, et al., D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice. J Neurosci. 2006 Mar 8;26(10):2814-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory