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Adora2atm1.1Dyj
Targeted Allele Detail
Nomenclature
Symbol: Adora2atm1.1Dyj
Name: adenosine A2a receptor; targeted mutation 1.1, Yuan-Ji Day
MGI ID: MGI:3625456
Synonyms: A2A-, Adora2atm1.1Masc
Gene: Adora2a  Location: Chr10:75316943-75334788 bp, + strand  Genetic Position: Chr10, 38.52 cM, cytoband B5.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104338
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsVariable germline expression of cre disrupted the targeted allele carrying floxed exon 2 resulting in removal of exon 2 in some gonadal cells, instead of the expected tissue-specific disruption of the floxed allele by the Camk2a-cre transgene. (J:104338)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adora2a Mutation:  16 strains or lines available
References
Original:  J:104338 Bastia E, et al., A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization. Neuropsychopharmacology. 2005 May;30(5):891-900
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory