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Ptprntm1Aln
Targeted Allele Detail
Summary
Symbol: Ptprntm1Aln
Name: protein tyrosine phosphatase receptor type N; targeted mutation 1, Abner Louis Notkins
MGI ID: MGI:3625093
Synonyms: IA-2-
Gene: Ptprn  Location: Chr1:75223671-75241146 bp, - strand  Genetic Position: Chr1, 38.64 cM
Alliance: Ptprntm1Aln page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108765
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was designed to replace sequence spanning from the 5' upstream promoter region to intron 3 with a neomycin resistance gene. Western blot failed to detect protein in mutant brain extract. (J:108765)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprn Mutation:  38 strains or lines available
References
Original:  J:108765 Saeki K, et al., Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion. Diabetes. 2002 Jun;51(6):1842-50
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory