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Tg(Ckm-LPL)MRze
Transgene Detail
Nomenclature
Symbol: Tg(Ckm-LPL)MRze
Name: transgene insertion M, Rudolf Zechner
MGI ID: MGI:3624977
Synonyms: MCK-M
Transgene: Tg(Ckm-LPL)MRze  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA/J)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ckm-LPL)MRze expresses 1 gene
 
Mutation detailsThis transgene consists of an LPL minigene containing the full-length human LPL cDNA including the 5' untranslated sequence, the complete coding region, the 3' untranslated sequence, and 339 bp of 3' flanking region under the control of the mouse muscle creatine kinase promoter. This line integrated an estimated number of 10 copies per genome and is the medium expression line. Human LPL is expressed in skeletal and cardiac muscle but not other tissues and there is an 8.1-fold increase in heparin releasable LPL activity in skeletal muscle. (J:101818)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:101818 Levak-Frank S, et al., Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J Clin Invest. 1995 Aug;96(2):976-86
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory