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Targeted Allele Detail
Symbol: Klrb1ctm1Tks
Name: killer cell lectin-like receptor subfamily B member 1C; targeted mutation 1, Takashi Saito
MGI ID: MGI:3624861
Gene: Klrb1c  Location: Chr6:128778485-128788641 bp, - strand  Genetic Position: Chr6, 63.09 cM
Mouse Generated:  Earliest citation of chimera generation: J:56645
Parent Cell Line:  BL/6-III (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    The initiation codon was replaced by DT-A and a neomycin resistance gene. (J:56645)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klrb1c Mutation:  5 strains or lines available
Analysis was performed in cells from chimeric mice only, not in mice with germline mutations. Cells expressing NKR-P1 (Klrb1c) were eliminated, and natural killer cell function in ES-cell derived lymphoid cells was abolished. Development of B and T cells was not affected by this mutation.
Original:  J:56645 Arase K, et al., Ablation of a specific cell population by the replacement of a uniquely expressed gene with a toxin gene. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9264-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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