A4galt^tm1Kfk
Targeted Allele Detail

Summary

• Symbol: A4galt^tm1Kfk
• Name: alpha 1,4-galactosyltransferase; targeted mutation 1, Koichi Furukawa
• MGI ID: MGI:3624807
• Synonyms: A3galt2^tm1Kfk, Alpha1,4Gal-T^-
• Gene: A4galt Location: Chr15:83110923-83135930 bp, - strand Genetic Position: Chr15, 39.4 cM
• Alliance: A4galt^tm1Kfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108352
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A vector was designed to replace nucleotides 68-615 of the ORF with a neomycin resistance gene. Northern blot did not detect transcript in mutants. (J:108352)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any A4galt Mutation: 60 strains or lines available

References

• Original: J:108352 Okuda T, et al., Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. J Biol Chem. 2006 Apr 14;281(15):10230-5
• All: 3 reference(s)