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H6pdtm1Pmst
Targeted Allele Detail
Nomenclature
Symbol: H6pdtm1Pmst
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); targeted mutation 1, Paul M Stewart
MGI ID: MGI:3624665
Gene: H6pd  Location: Chr4:149979475-150009023 bp, - strand  Genetic Position: Chr4, 80.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108281
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced by a neomycin resistance gene. Absence of protein was confirmed by immunoblot of mutant liver microsomes. (J:108281)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any H6pd Mutation:  24 strains or lines available
References
Original:  J:108281 Lavery GG, et al., Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. J Biol Chem. 2006 Mar 10;281(10):6546-51
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory