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Cochtm1.1Stw
Targeted Allele Detail
Nomenclature
Symbol: Cochtm1.1Stw
Name: coagulation factor C homolog (Limulus polyphemus); targeted mutation 1.1, Colin L Stewart
MGI ID: MGI:3624560
Synonyms: Coch-
Gene: Coch  Location: Chr12:51593341-51605773 bp, + strand  Genetic Position: Chr12, 22.11 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105566
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 7-11 and part of exon 12, encoding the two vWA domains and remaining cochlin protein downstream of the LCCL domain, were removed via cre mediated recombination. Neither full length or truncated transcripts were detected in mutants. (J:105566)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Coch Mutation:  7 strains or lines available
References
Original:  J:105566 Rodriguez CI, et al., Cochlin, a secreted von Willebrand factor type a domain-containing factor, is regulated by leukemia inhibitory factor in the uterus at the time of embryo implantation. Endocrinology. 2004 Mar;145(3):1410-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory