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Targeted Allele Detail
Symbol: Rb1tm1.2Gfk
Name: RB transcriptional corepressor 1; targeted mutation 1.2, Graham F Kay
MGI ID: MGI:3624441
Synonyms: Rb1deltaX2
Gene: Rb1  Location: Chr14:73192858-73325951 bp, - strand  Genetic Position: Chr14, 38.73 cM, cytoband D3
Germline Transmission:  Earliest citation of germline transmission: J:108628
Parent Cell Line:  C1368 (ES Cell)
Strain of Origin:  129T2/SvEms
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette flanked by FRT sites and with a 5' loxP site was inserted in intron 1. An additional loxP site was also inserted in intron 2. The neomycin cassette was subsequently excised by crossing with flpe-deleter mice. Exon 2 was then removed by crossing with Tg(CMV-cre)1Cgn mice. (J:108628)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rb1 Mutation:  78 strains or lines available
Original:  J:108628 Tonks ID, et al., Melanocytes in conditional Rb-/- mice are normal in vivo but exhibit proliferation and pigmentation defects in vitro. Pigment Cell Res. 2005 Aug;18(4):252-64
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory