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Trp53tm3Wahl
Targeted Allele Detail
Nomenclature
Symbol: Trp53tm3Wahl
Name: transformation related protein 53; targeted mutation 3, Geoffrey M Wahl
MGI ID: MGI:3624429
Synonyms: p53deltaP
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108183
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting construct was used to remove six prolines and both PXXP motifs. Quantification of mRNAs from mutant and wild-type demonstrated identical transcription from both alleles. (J:108183)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  133 strains or lines available
References
Original:  J:108183 Toledo F, et al., A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell. 2006 Apr;9(4):273-85
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory