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Igkctm1Schz
Targeted Allele Detail
Nomenclature
Symbol: Igkctm1Schz
Name: immunoglobulin kappa constant; targeted mutation 1, Pierre Sanchez
MGI ID: MGI:3624131
Synonyms: Ckappa-
Gene: Igkc  Location: Chr6:70726435-70726966 bp, + strand  Genetic Position: Chr6, 32.04 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108003
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into the HpaI site of the constant kappa segment. Mutant mice did not express the kappa light chain in B cells. (J:108003)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igkc Mutation:  4 strains or lines available
References
Original:  J:108003 Sanchez P, et al., Compartmentalization of lambda subtype expression in the B cell repertoire of mice with a disrupted or normal C kappa gene segment. Int Immunol. 1994 May;6(5):711-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory