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Targeted Allele Detail
Symbol: Espl1tm1.2Tno
Name: extra spindle pole bodies 1, separase; targeted mutation 1.2 Tetsuo Noda
MGI ID: MGI:3624003
Synonyms: Separasenull
Gene: Espl1  Location: Chr15:102296266-102324357 bp, + strand  Genetic Position: Chr15, 57.45 cM
Germline Transmission:  Earliest citation of germline transmission: J:107917
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA 1.4 kb genomic segment including exon 6 was removed via cre mediated recombination. RT-PCR detected reduced amounts of transcript in heterozygotes. Sequencing revealed that the splicing of exons 5-7, which encode a frame shift mutation at codon 452, generated this transcript. (J:107917)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Espl1 Mutation:  6 strains or lines available
Original:  J:107917 Kumada K, et al., The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase. J Cell Biol. 2006 Mar 13;172(6):835-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory