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Trp53tm2Wahl
Targeted Allele Detail
Summary
Symbol: Trp53tm2Wahl
Name: transformation related protein 53; targeted mutation 2, Geoffrey M Wahl
MGI ID: MGI:3623943
Synonyms: p537KR, Trp-537KR
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm2Wahl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100189
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA targeting construct was designed to change the seven C-terminal lysines to arginine (p.K367R, p.K369R, p.K370R, p.K378R, p.K379R, p.K383R, p.K384R). A loxP site flanked neomycin resistance gene cassette was included in the vector, which was electroporated into ES cells carrying a self-excising cre recombinase gene. (J:100189)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  232 strains or lines available
References
Original:  J:100189 Krummel KA, et al., The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10188-93
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory