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Targeted Allele Detail
Symbol: Trp53tm2Wahl
Name: transformation related protein 53; targeted mutation 2, Geoffrey M Wahl
MGI ID: MGI:3623943
Synonyms: p537KR, Trp-537KR
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Germline Transmission:  Earliest citation of germline transmission: J:100189
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA targeting construct was designed to change the 7 c-terminal lysines to arginine. A floxed neo was included in the vector, which was electroporated into ES cells containing a self-excising cre recombinase. (J:100189)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  141 strains or lines available
Original:  J:100189 Krummel KA, et al., The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10188-93
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory