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Targeted Allele Detail
Symbol: Dnah11tm1Bknr
Name: dynein, axonemal, heavy chain 11; targeted mutation 1, Martina Brueckner
MGI ID: MGI:3623682
Synonyms: LrdGFPdeltaneo
Gene: Dnah11  Location: Chr12:117877982-118199043 bp, - strand  Genetic Position: Chr12, 63.25 cM
Germline Transmission:  Earliest citation of germline transmission: J:107740
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA targeting vector was used to insert a GFP immediately downstream of the ATG in exon 1. A floxed neomycin resistance gene was included in the vector. Aberrant splicing resulted in failure in expression of GFP or full length endogenous transcripts. (J:107740)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnah11 Mutation:  14 strains or lines available
Original:  J:107740 McGrath J, et al., Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell. 2003 Jul 11;114(1):61-73
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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