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Kif2atm1Noh
Targeted Allele Detail
Nomenclature
Symbol: Kif2atm1Noh
Name: kinesin family member 2A; targeted mutation 1, Nobutaka Hirokawa
MGI ID: MGI:3623680
Synonyms: Kif2a-, Kif2aGt(Betageo)1Noh
Gene: Kif2a  Location: Chr13:106960585-107022476 bp, - strand  Genetic Position: Chr13, 58.06 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107737
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA betageo replaced 0.9 kb coding region of the ATP binding consensus P loop of the motor domain by a promoter gene trap strategy. The vector was designed to create a frame shift and also disrupt the beta splicing isoform. Western blot confirmed ablation of protein. (J:107737)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kif2a Mutation:  19 strains or lines available
References
Original:  J:107737 Homma N, et al., Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell. 2003 Jul 25;114(2):229-39
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory