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Recktm1Ito
Targeted Allele Detail
Nomenclature
Symbol: Recktm1Ito
Name: reversion-inducing-cysteine-rich protein with kazal motifs; targeted mutation 1, Shigeyoshi Itohara
MGI ID: MGI:3623517
Synonyms: Reck-
Gene: Reck  Location: Chr4:43875530-43944806 bp, + strand  Genetic Position: Chr4, 23.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107674
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 1 with a PGK-neo cassette. Northern and Western blot analyses confirmed absence of transcript and protein, respectively. (J:107674)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Reck Mutation:  36 strains or lines available
References
Original:  J:107674 Oh J, et al., The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell. 2001 Dec 14;107(6):789-800
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/26/2022
MGI 6.21
The Jackson Laboratory