Angptl3^tm1Kfuj
Targeted Allele Detail

Summary

• Symbol: Angptl3^tm1Kfuj
• Name: angiopoietin-like 3; targeted mutation 1, Kazunori Fujimoto
• MGI ID: MGI:3623491
• Gene: Angptl3 Location: Chr4:98919191-98926429 bp, + strand Genetic Position: Chr4, 45.6 cM
• Alliance: Angptl3^tm1Kfuj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107479
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire locus except for part of exon 1 , was replaced with a neomycin resistance gene. Northern blot demonstrated that transcript was not detected in mutants. (J:107479)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angptl3 Mutation: 35 strains or lines available

References

• Original: J:107479 Fujimoto K, et al., Angptl3-null mice show low plasma lipid concentrations by enhanced lipoprotein lipase activity. Exp Anim. 2006 Jan;55(1):27-34
• All: 2 reference(s)