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Cdkn1btm3Mlf
Targeted Allele Detail
Nomenclature
Symbol: Cdkn1btm3Mlf
Name: cyclin-dependent kinase inhibitor 1B; targeted mutation 3, Matthew L Fero
MGI ID: MGI:3623441
Synonyms: p27S-, p27stop
Gene: Cdkn1b  Location: Chr6:134920401-134925513 bp, + strand  Genetic Position: Chr6, 65.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107588
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA floxed transcriptional stop cassette was inserted into the 5' UTR. Protein was nearly undetectable in mutants. (J:107588)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1b Mutation:  13 strains or lines available
References
Original:  J:107588 Chien WM, et al., Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4122-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory