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Targeted Allele Detail
Symbol: Jag1tm1Jlew
Name: jagged 1; targeted mutation 1, Julian Lewis
MGI ID: MGI:3623344
Synonyms: Jag1flox
Gene: Jag1  Location: Chr2:137081456-137116644 bp, - strand  Genetic Position: Chr2, 67.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:107414
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were inserted to flank exons encoding the DSL (Delta-Serrate-Lag2) domain required for binding to Notch. Expression of cre recombinase is expected to knock out gene function by removing exons 4 and 5 (the DSL encoding exons) and causing a frame shift that generates a stop codon after the start of exon 6. (J:107414)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jag1 Mutation:  8 strains or lines available
Original:  J:107414 Brooker R, et al., Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development. 2006 Apr;133(7):1277-86
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory