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Gabra5tm1Twr
Targeted Allele Detail
Summary
Symbol: Gabra5tm1Twr
Name: gamma-aminobutyric acid type A receptor subunit alpha 5; targeted mutation 1, Thomas W Rosahl
MGI ID: MGI:3623342
Synonyms: alpha5-
Gene: Gabra5  Location: Chr7:57057420-57159807 bp, - strand  Genetic Position: Chr7, 33.52 cM
Alliance: Gabra5tm1Twr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108206
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 3 with a neomycin resistance gene. Western blot analysis failed to detect protein in mutant hippocampus. (J:108206)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabra5 Mutation:  30 strains or lines available
References
Original:  J:108206 Collinson N, et al., Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor. J Neurosci. 2002 Jul 1;22(13):5572-80
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory