About   Help   FAQ
Isl1tm1(cre)Sev
Targeted Allele Detail
Nomenclature
Symbol: Isl1tm1(cre)Sev
Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Sylvia Evans
MGI ID: MGI:3623159
Synonyms: Isl1Cre, Isl1Cre, Isl1:Cre
Gene: Isl1  Location: Chr13:116298281-116309689 bp, - strand  Genetic Position: Chr13, 64.87 cM, cytoband D2.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107396
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/Sv
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA cre gene and frt-flanked neo cassette were inserted 6 bp upstream of the translation initiation codon. The neo cassette was removed by germ line, flp-mediated recombination. Expression of cre is regulated by the endogenous promoter. (J:107396)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Isl1     Summary of all recombinase alleles driven by Isl1.
 

Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Isl1 Mutation:  8 strains or lines available
References
Original:  J:107396 Yang L, et al., Isl1Cre reveals a common Bmp pathway in heart and limb development. Development. 2006 Apr;133(8):1575-85
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory