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Ppardtm1Dsvg
Targeted Allele Detail
Nomenclature
Symbol: Ppardtm1Dsvg
Name: peroxisome proliferator activator receptor delta; targeted mutation 1, Beatrice Desvergne
MGI ID: MGI:3623147
Synonyms: PPARbeta-
Gene: Ppard  Location: Chr17:28232754-28301469 bp, + strand  Genetic Position: Chr17, 14.64 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107381
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 4 and most of 5 with a PGK-neo cassette. The deleted sequence encodes the DNA-binding domain. Western blot confirmed absence of protein in mutant nuclear extracts. (J:107381)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppard Mutation:  60 strains or lines available
References
Original:  J:107381 Nadra K, et al., Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol Cell Biol. 2006 Apr;26(8):3266-81
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory