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Targeted Allele Detail
Symbol: Hcls1tm1Wtn
Name: hematopoietic cell specific Lyn substrate 1; targeted mutation 1, Takeshi Watanabe
MGI ID: MGI:3623117
Synonyms: HS15'ko
Gene: Hcls1  Location: Chr16:36934983-36963212 bp, + strand  Genetic Position: Chr16, 26.3 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:28146
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with a neomycin resistance gene in reverse orientation. Exon 2 contains the ATG. Protein was not detected in mutants. (J:28146)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcls1 Mutation:  2 strains or lines available
Original:  J:28146 Taniuchi I, et al., Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases. EMBO J. 1995 Aug 1;14(15):3664-78
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory