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Ednrbtm3(tetO)Tilg
Targeted Allele Detail
Summary
Symbol: Ednrbtm3(tetO)Tilg
Name: endothelin receptor type B; targeted mutation 3, Shirley M Tilghman
MGI ID: MGI:3623112
Synonyms: EdnrbtetO
Gene: Ednrb  Location: Chr14:104052061-104081838 bp, - strand  Genetic Position: Chr14, 53.05 cM
Alliance: Ednrbtm3(tetO)Tilg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58698
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Inducible)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Mutation detailsThe region from 550 base pairs upstream of the putative promoter to 240 base pairs downstream of the exon 1/intron 1 junction was replaced with a cassette encoding the a tet-responsive promoter that directs expression of Ednrb cDNA. Also included in the vector is a floxed hygromycin resistance gene. (J:58698)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ednrb Mutation:  103 strains or lines available
References
Original:  J:58698 Shin MK, et al., The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature. 1999 Dec 2;402(6761):496-501
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory