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Ts(16C-tel)1Cje
Spontaneous Allele Detail
Nomenclature
Symbol: Ts(16C-tel)1Cje
Name: trisomy, (16C-tel), 1 Charles J Epstein
MGI ID: MGI:3623022
Synonyms: partial trisomy 16, Ts108Cje, Ts(1216)1Cje, Ts1Cje
Gene: Ts(16C-tel)1Cje  Location: unknown  Genetic Position: Chr16, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47907
Parent Cell Line:  CB1-4 (ES Cell)
Strain of Origin:  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Mutation
description
Allele Type:    Spontaneous
Mutation:    Translocation
 
Mutation detailsThis chromosomal trisomy comprises two normal Chr 16s and the reciprocal translocation product 1216. Mice are trisomic for the cytogenetic interval 16C-tel and the genetic interval Sod1 to Mx1. Sod1 is not functionally trisomic because the Sod1 gene in the translocated segment is inactivated by the insertion of the neomycin resistance sequence. The Ts1Cje mouse model of Down syndrome is trisomic for 94 genes on Mmu16, covering approximately two-thirds of the trisomic region in Ts65Dn mice. (J:47907, J:160790)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ts(16C-tel)1Cje Mutation:  2 strains or lines available
References
Original:  J:47907 Sago H, et al., Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6256-61
All:  48 reference(s)

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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory