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Tg(INS-Il10)#Sar
Transgene Detail
Nomenclature
Symbol: Tg(INS-Il10)#Sar
Name: transgene insertion #, Nora Sarvetnick
MGI ID: MGI:3622661
Transgene: Tg(INS-Il10)#Sar  Location: unknown  
Tg(INS-Il10)#Sar/0 mice accumulate imflammatory cells within exocrine pancreatic tissue

Show the 1 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  Not Applicable
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(INS-Il10)#Sar expresses 1 gene
 
Mutation detailsA 594-bp fragment encoding the murine Il10 was inserted behind the human insulin promoter which is in a vector also containing the termination sequence from the hepatitis B virus gene. Il10 is expressed by the islet of Langerhans cells in the pancreas. (J:107927)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:107927 Wogensen L, et al., Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans. J Exp Med. 1993 Jul 1;178(1):175-85
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory