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Transgene Detail
Symbol: Tg(Fabp4-Hsd11b1)7Jesf
Name: transgene insertion 7, Jeffrey S Flier
MGI ID: MGI:3622478
Synonyms: aP2-HSD1
Transgene: Tg(Fabp4-Hsd11b1)7Jesf  Location: unknown  
Strain of Origin:  FVB
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThis transgene consists of the rat Hsd11b1 gene under the control of the enhancer-promoter region of the adipocyte fatty acid binding protein (Fabp4) gene. Hsd11b1 transcript is expressed equivalently in adipose tissue from subcutaneous, abdominal, epididymal, mesenteric, and interscapular brown adipose tissue depots but is absent in brain, liver, skeletal muscle and kidney. Hsd11b1 mRNA is increased 7-fold compared to endogenous mRNA and activity is increased 2.4-fold in subcutaneous abdominal fat and 2.7-fold in epididymal fat. (J:107046)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Phenotypic Similarity to Human Syndrome: Abdominal Obesity-Metabolic Syndrome in hemizygous mice (J:107046)

Original:  J:107046 Masuzaki H, et al., A transgenic model of visceral obesity and the metabolic syndrome. Science. 2001 Dec 7;294(5549):2166-70
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
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