About   Help   FAQ
Braftm1.1Sva
Targeted Allele Detail
Nomenclature
Symbol: Braftm1.1Sva
Name: Braf transforming gene; targeted mutation 1.1, Alcino Silva
MGI ID: MGI:3622462
Synonyms: B-raf-, B-rafdelta, B-rafexon12-, Brafexon9, Mox2cre;B-rafdelta
Gene: Braf  Location: Chr6:39603237-39725463 bp, - strand  Genetic Position: Chr6, 18.43 cM
Embryonic development abnormalities in Braftm1.1Sva/Braftm1.1Sva mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105998
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed sequence containing the first exon to encode the kinase domain (exon 12; exon 9 according to nomenclature in J:29234) was removed via cre mediated recombination. (J:105998)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Braf Mutation:  30 strains or lines available
References
Original:  J:105998 Galabova-Kovacs G, et al., Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1325-30
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory