About   Help   FAQ
Braftm1.1Sva
Targeted Allele Detail
Nomenclature
Symbol: Braftm1.1Sva
Name: Braf transforming gene; targeted mutation 1.1, Alcino Silva
MGI ID: MGI:3622462
Synonyms: B-raf-, B-rafdelta, B-rafexon12-, Brafexon9, Mox2cre;B-rafdelta
Gene: Braf  Location: Chr6:39603237-39725463 bp, - strand  Genetic Position: Chr6, 18.43 cM
Embryonic development abnormalities in Braftm1.1Sva/Braftm1.1Sva mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105998
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed sequence containing the first exon to encode the kinase domain (exon 12; exon 9 according to nomenclature in J:29234) was removed via cre mediated recombination. (J:105998)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Braf Mutation:  32 strains or lines available
References
Original:  J:105998 Galabova-Kovacs G, et al., Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1325-30
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/14/2017
MGI 6.08
The Jackson Laboratory