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Targeted Allele Detail
Symbol: Braftm1.1Sva
Name: Braf transforming gene; targeted mutation 1.1, Alcino Silva
MGI ID: MGI:3622462
Synonyms: B-raf-, B-rafdelta, B-rafexon12-, Brafexon9, Mox2cre;B-rafdelta
Gene: Braf  Location: Chr6:39603237-39725463 bp, - strand  Genetic Position: Chr6, 18.43 cM
Embryonic development abnormalities in Braftm1.1Sva/Braftm1.1Sva mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:105998
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe floxed sequence containing the first exon to encode the kinase domain (exon 12; exon 9 according to nomenclature in J:29234) was removed via cre mediated recombination. (J:105998)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Braf Mutation:  13 strains or lines available
Original:  J:105998 Galabova-Kovacs G, et al., Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1325-30
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory