Ern1^tm1Rjk
Targeted Allele Detail

Summary

• Symbol: Ern1^tm1Rjk
• Name: endoplasmic reticulum to nucleus signalling 1; targeted mutation 1, Randal J Kaufman
• MGI ID: MGI:3622330
• Synonyms: ire1alpha
• Gene: Ern1 Location: Chr11:106285476-106378678 bp, - strand Genetic Position: Chr11, 69.14 cM, cytoband E1
• Alliance: Ern1^tm1Rjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107824
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo replaced exons 7 through 14. Northern and Western blot confirmed recombination and the expression of a smaller transcript than that found in wild-type MEFs. (J:107824)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ern1 Mutation: 57 strains or lines available

References

• Original: J:107824 Lee K, et al., IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 2002 Feb 15;16(4):452-66
• All: 11 reference(s)