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Ern1tm1Rjk
Targeted Allele Detail
Nomenclature
Symbol: Ern1tm1Rjk
Name: endoplasmic reticulum (ER) to nucleus signalling 1; targeted mutation 1, Randal J Kaufman
MGI ID: MGI:3622330
Synonyms: ire1alpha
Gene: Ern1  Location: Chr11:106397620-106487796 bp, - strand  Genetic Position: Chr11, 69.14 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107824
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo replaced exons 7 through 14. Northern and Western blot confirmed recombination and the expression of a smaller transcript than that found in wild-type MEFs. (J:107824)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ern1 Mutation:  8 strains or lines available
References
Original:  J:107824 Lee K, et al., IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 2002 Feb 15;16(4):452-66
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory