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Abcc2tm1Ahs
Targeted Allele Detail
Nomenclature
Symbol: Abcc2tm1Ahs
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 2; targeted mutation 1, Alfred H Schinkel
MGI ID: MGI:3621934
Synonyms: Mrp2-, Mrp20
Gene: Abcc2  Location: Chr19:43782308-43838332 bp, + strand  Genetic Position: Chr19, 36.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107822
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.7 kb fragment containing exons 4-6 was replaced with an inverted Pgk selection cassette. Complete absence of protein product was confirmed by Western blot analysis. (J:107822)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abcc2 Mutation:  8 strains or lines available
References
Original:  J:107822 Vlaming ML, et al., Carcinogen and anti-cancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice. J Pharmacol Exp Ther. 2006 Jul;318(1):319-27
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory