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Targeted Allele Detail
Symbol: Nespastm1Jop
Name: neuroendocrine secretory protein antisense; targeted mutation 1, Jo Peters
MGI ID: MGI:3621477
Synonyms: deltaNAS-DMR, Nespastm1Jop
Gene: Nespas  Location: Chr2:174281237-174295436 bp, - strand  Genetic Position: Chr2, 97.89 cM
Germline Transmission:  Earliest citation of germline transmission: J:106793
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to delete 1.6 kb of genomic sequence covering the promoter, exon 1 and 631 bp of intronic sequence, leaving the Gnas minimum promoter region intact. The vector included a tACE-Cre gene for excision of the cassette in the male germ line. RT-PCR failed to detect transcript in paternally inherited mutants. (J:106793)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nespas Mutation:  7 strains or lines available
Original:  J:106793 Williamson CM, et al., Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster. Nat Genet. 2006 Mar;38(3):350-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.08
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